Description
The HBOC Basic Panel is a focused hereditary cancer genetic test designed to detect mutations in the most clinically significant genes associated with Hereditary Breast and Ovarian Cancer (HBOC) syndrome. This panel evaluates high-risk genes including BRCA1 gene, BRCA2 gene, PALB2 gene, and TP53 gene.
Mutations in these genes significantly increase the lifetime risk of breast cancer, ovarian cancer, prostate cancer, and other hereditary cancers. This Next-Generation Sequencing (NGS)-based panel supports early cancer detection, risk assessment, and precision oncology treatment planning. Non-fasting.
Sample Required:
The HBOC Basic Panel requires a blood sample, collected in an EDTA vacutainer (purple top). The sample must be transported under refrigerated conditions (2–8°C) within 72 hours.
Test Time:
The test results are typically available within 10–14 days, depending on sequencing workflows.
Test Normal Range:
The normal result is no pathogenic or likely pathogenic mutations detected in the tested genes.
- Negative: No clinically significant mutations identified
- Positive: Pathogenic mutation detected (increased cancer risk)
- VUS (Variant of Uncertain Significance): Requires clinical correlation
What is the test?
The HBOC Basic Panel is a targeted genetic screening test used for identifying inherited mutations in key genes linked to hereditary breast and ovarian cancers. It is widely used in cancer genomics, precision medicine, and hereditary cancer risk assessment.
This test helps:
- Detect high-risk genetic mutations early
- Enable personalized treatment strategies (e.g., PARP inhibitors)
- Support preventive oncology and surveillance planning
Test Procedure:
A blood sample is collected and analyzed using high-depth NGS technology (~450x coverage). The DNA is sequenced to detect mutations, insertions, deletions, and copy number variations in the selected genes. Results are interpreted by molecular genetic experts and oncologists.
When to take the test?
This test is recommended in the following scenarios:
- Early-onset breast or ovarian cancer
- Bilateral breast cancer or multiple primary cancers
- Family history of HBOC-related cancers
- Prostate or peritoneal cancers with hereditary risk
- Individuals of Ashkenazi Jewish descent
- Prior to targeted therapy or surgical decision-making
Who should take this test?
- Individuals with a strong family history of breast or ovarian cancer
- Patients with early-onset or aggressive cancers
- Families with known BRCA or related gene mutations
- Individuals seeking genetic counseling and cancer risk assessment
- Patients planning preventive or precision oncology strategies
Precautions for exceptional cases (pregnancy etc.):
Pregnant individuals or those with existing medical conditions should consult their healthcare provider before testing. Genetic counseling is strongly recommended to understand test results and implications for family members.
Genes Covered
- BRCA1
- BRCA2
- PALB2
- TP53
Indications for Testing
- Early-onset breast, ovarian, or bilateral breast cancer
- Family history of HBOC-related cancers
- Prostate or peritoneal cancers with hereditary risk
- Known familial mutation in BRCA/PALB2/TP53 genes
- Planning personalized treatment and preventive strategies
Inheritance Pattern
These genes follow an autosomal dominant inheritance pattern:
- A single mutated gene increases cancer risk
- 50% chance of inheritance among first-degree relatives
- Supports family-wide genetic screening
Why is This Test Important?
The HBOC Basic Panel enables:
- Early identification of hereditary cancer risk
- Personalized treatment and targeted therapy selection
- Informed decisions on preventive surgeries and surveillance
- Improved clinical outcomes through early intervention
Applicable Cancers
- Hereditary Breast and Ovarian Cancer (HBOC)
- Breast Cancer
- Ovarian Cancer
- Prostate Cancer
- Pancreatic Cancer
Technical Information
- Methodology: Next-Generation Sequencing (NGS)
- Depth of Coverage: ~450x (high sensitivity and accuracy)
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