Description
The HBOC Comprehensive Panel is an advanced Next-Generation Sequencing (NGS)-based genetic test designed to identify inherited mutations associated with Hereditary Breast and Ovarian Cancer (HBOC) and related cancer syndromes. This expanded panel evaluates 20 clinically significant genes, including high-risk genes like BRCA1 gene, BRCA2 gene, and TP53 gene, along with moderate-risk genes such as ATM gene, CHEK2 gene, and PALB2 gene.
This comprehensive cancer gene panel enhances genetic risk assessment, early cancer detection, and precision oncology treatment planning, making it ideal for individuals with complex personal or family cancer histories. Non-fasting.
Sample Required:
The HBOC Comprehensive Panel requires a blood sample, collected in an EDTA vacutainer (purple top). The sample must be transported under refrigerated conditions (2–8°C) within 72 hours.
Test Time:
The test results are typically available within 12–14 days, depending on sequencing and reporting timelines.
Test Normal Range:
The normal result is no pathogenic or likely pathogenic mutations detected in the tested genes.
- Negative: No clinically significant mutations identified
- Positive: Pathogenic mutation detected (increased cancer risk)
- VUS (Variant of Uncertain Significance): Requires expert genetic counseling
What is the test?
The HBOC Comprehensive Panel is a broad-spectrum hereditary cancer genetic test that analyzes multiple genes associated with breast, ovarian, and related cancers. It is widely used in cancer genomics, precision medicine, and hereditary cancer screening programs.
This test helps:
- Identify high-risk and moderate-risk genetic mutations
- Enable personalized cancer treatment (targeted therapy, PARP inhibitors)
- Support preventive oncology and surveillance strategies
Test Procedure:
A blood sample is collected and processed using high-depth NGS technology (~450x coverage). DNA is extracted and sequenced to detect mutations, insertions, deletions, and copy number variations across 20 genes. Results are interpreted by molecular geneticists and oncologists.
When to take the test?
This test is recommended in the following scenarios:
- Personal or family history of multiple cancers
- Early-onset or bilateral breast cancer
- Individuals with two primary or recurrent cancers
- Before risk-reducing surgeries (mastectomy/oophorectomy)
- For advanced cancer risk stratification and treatment planning
Who should take this test?
- Individuals with complex hereditary cancer history
- Patients with aggressive or early-onset cancers
- Families with multiple cancer syndromes
- Individuals seeking comprehensive genomic cancer screening
- Patients planning precision oncology-based treatments
Precautions for exceptional cases (pregnancy etc.):
Pregnant individuals or those with existing medical conditions should consult their healthcare provider before testing. Genetic counseling is strongly recommended before and after testing to understand medical and familial implications.
Genes Covered
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, NF1, PALB2, PMS2, PTEN, RAD51C, RAD51D, STK11, TP53
Indications for Testing
- Personal or family history of multiple cancer types
- Early-onset or bilateral breast cancer
- Individuals with recurrent or multiple primary cancers
- Candidates for preventive surgeries
- Need for advanced genetic risk profiling
Inheritance Pattern
Most genes in this panel follow an autosomal dominant inheritance pattern, while a few may have autosomal recessive inheritance:
- Increased cancer risk with a single mutated gene
- 50% inheritance risk for first-degree relatives
- Enables family-wide screening and preventive care
Why is This Test Important?
The HBOC Comprehensive Panel enables:
- Comprehensive hereditary cancer risk assessment
- Personalized treatment planning and targeted therapy selection
- Identification of high-risk individuals for early intervention
- Better long-term outcomes through proactive cancer care
Applicable Cancers
- Hereditary Breast and Ovarian Cancer (HBOC)
- Breast Cancer
- Ovarian Cancer
- Prostate Cancer
- Pancreatic Cancer
- Endometrial Cancer
- Gastrointestinal Cancers (Lynch syndrome-related)
Technical Information
- Methodology: Next-Generation Sequencing (NGS)
- Depth of Coverage: ~450x (high sensitivity and accuracy)
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